Acta Medica International

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 4  |  Issue : 1  |  Page : 51--55

Soluble HLA-G: A novel marker in acute myeloid leukemia patients


Nahla Abdel Moneim Hamed1, Nabil El Halawani1, Dalia Nafea1, Mohamed Abd El Rahman2, Ahmed Kasber3 
1 Department of Clinical Haematology, Faculty of Medicine, Alexandria University, Alexandria, Egypt
2 Department of Clinical Pathology, Military Medical Academy, Alexandria, Egypt
3 Department of Clinical Haematology, Military Medical Academy, Alexandria, Egypt

Correspondence Address:
Nahla Abdel Moneim Hamed
Department of Clinical Haematology, Faculty of Medicine, Alexandria University, Alexandria
Egypt

Objective: to study soluble HLA-G (sHLA-G) in Egyptian acute myeloid leukemia (AML) patients. HLA-G is speculated to be a tumor-driven immune escape mechanism. In addition, it might be a promising target for future immune therapeutic approaches. Methods: Thirty AML patients and 15 healthy controls of matched age and sex were the subject of the study. sHLA-G was done to all patients and controls by ELISA. Results: Statistically significant increase in sHLA-G level was present in AML patients compared to controls, being higher in relapsed cases. HLA-G levels was correlated to bone marrow blast percentages but not affected by age, gender, WBCs or response to chemotherapy. HLA-G had a sensitivity of 100% and a specificity of 62% to detect AML cases. Conclusion: HLA-G may be an additional marker for AML especially relapsed cases


How to cite this article:
Hamed NA, El Halawani N, Nafea D, El Rahman MA, Kasber A. Soluble HLA-G: A novel marker in acute myeloid leukemia patients.Acta Med Int 2017;4:51-55


How to cite this URL:
Hamed NA, El Halawani N, Nafea D, El Rahman MA, Kasber A. Soluble HLA-G: A novel marker in acute myeloid leukemia patients. Acta Med Int [serial online] 2017 [cited 2022 May 19 ];4:51-55
Available from: https://www.actamedicainternational.com/article.asp?issn=2349-0578;year=2017;volume=4;issue=1;spage=51;epage=55;aulast=Hamed;type=0