Larynx preservation rate in laryngeal cancer patients treated with chemotherapy and radiotherapy: An institutional review of 250 patients
Sumit Goyal1, Pooja Nandwani Patel2, Mehul Gohil2, U Suryanarayana3
1 Junior Lecturer, Department of Radiation Oncology, Gujarat Cancer and Research Institute, Ahmadabad, Gujarat, India
2 Associate Professor, Department of Radiation Oncology, Gujarat Cancer and Research Institute, Ahmadabad, Gujarat, India
3 Professor and Head, Department of Radiotherapy, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India
Junior Lecturer, Department of Radiotherapy, Gujarat Cancer and Research Institute, Asarwa, B-803 Spectrum Towers, Shahibaug, Ahmedabad, Gujarat-380004
Source of Support: None, Conflict of Interest: None
Introduction: Chemo-radiation preceded by induction chemotherapy is reported valuable alternative to laryngectomy in laryngeal cancer for larynx preservation.This study was performed to assess the influence chemo radiation on preservation of larynx.
Materials and Methods: Two hundred and fifty sequential patients treated from January 2012 to December 2012 in our institute were reviewed and who were available for follow-up in this retrospective study. Total dose of 66-70 Gray was used at 2 gray per fraction daily for five days week were used. Larynx preservation rate at 3 years of median follow-up were analyzed.
Results: Among 250 patients, larynx preservation was possible in 170 patients (68%). With chemo-radiation, excellent preservation of larynx was achieved in stage II (78%) disease, while in advanced stage III and stage IVA, larynx preservation was 67.06% and 64.35%, respectively.
Conclusion: Chemo-radiation (either neoadjuvant chemotherapy followed by chemo-radiation or concurrent chemo-radiation) has better larynx preservation rate in early as well was advanced laryngeal cancer patients.