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Year : 2016  |  Volume : 3  |  Issue : 1  |  Page : 46-49

Outcomes of GnRH agonist and GnRH antagonist regimens for IVF in women aged up to 40

GENESIS – Center for Assistance in Human Reproduction, Brasília, Distrito Federal, Brazil

Correspondence Address:
Bruno Ramalho de Carvalho
Bruno Ramalho de Carvalho. Genesis - Center for Assistance in Human Reproduction. SHLS 716, Bloco“L”, Salas “L” 328/331, Centro Clínico Sul - Ala Leste. Brasília, Distrito Federal
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Source of Support: None, Conflict of Interest: None

DOI: 10.5530/ami.2016.1.11

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Objective: To compare outcomes among good-prognosis patients undergoing in vitro fertilization and intracytoplasmic sperm injection followed by embryo transfer (IVF/ICSI-ET) in GnRH-agonist (GnRH-a) and GnRH-antagonist (GnRH-ant) regimens. Methods: Retrospective analysis of 434 IVF/ICSI-ET cycles performed in a private center, in women aged up to 40: GnRH-a (n = 291) and GnRH-ant (n = 143). Pre-gestational, gestational and perinatal outcomes were evaluated. Statistical analysis was performed by unpaired t-test, Mann-Whitney test and Fisher's exact test. Significance was set at p < 0.05. Results: GnRH-a regimen was associated with higher amounts of total oocytes (10.7 ± 5.7 vs 9.3 ± 5.7, p < 0.001), mature oocytes (8.2 ± 4,5 vs 6.8 ± 4.4, p < 0.001) and good quality embryos transferred (1.7 ± 0.8 vs 1.5 ± 0.9; p < 0.05). Rates of fertilization, embryo implantation and live births were also higher in GnRH-a (72.8%, 27.6% and 48.8%, respectively) compared to GnRH-ant (65.3%, 14.7% and 26.6%, respectively; p < 0.0001). There were no significant differences between rates of preterm delivery or low birth weight, comparing the two groups. Conclusion: Our results suggest that the long GnRH-a regimen is the one that offers the best reproductive outcomes among in women aged up to 40 undergoing IVF/ICSI-ET.

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