• Users Online: 164
  • Print this page
  • Email this page
Year : 2016  |  Volume : 3  |  Issue : 1  |  Page : 151-153

Histopathological evaluation of patients with mycosis fungoides before and after phototherapy

1 Autoimmune Bullous Diseases Research Center, Department of Dermatology, Razi Dermatology Hospital, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Dermatopathology, Razi Dermatology Hospital, Tehran University of Medical Sciences, Tehran, Iran
3 Department of Dermatopathology, Razi Dermatology Hospital; Department of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

Correspondence Address:
Alireza Ghanadan
Associate professor of Pathology, Department of dermatopathology, Razi Dermatology Hospital, Vahdate Eslami Street, Tehran
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.5530/ami.2016.1.31

Rights and Permissions

Background and Objectives: Mycosis fungoides (MF) is the most common type of cutaneous lymphoma accompanied by neoplastic T cells. Histopathological changes after phototherapy could be an effective index for evaluation of treatment. The aim of this study was to compare histomorphological changes in Iranian MF patients before and after phototherapy. Methods: Skin biopsies of 20 diagnosed MF patients in Razi dermatology Hospital of Tehran University of Medical Sciences were evaluated based on major and minor diagnostic criteria using Guitart classification to assess histological features of phototherapy. Result: Of 20 studied patients eight patients were man and 12 were woman. Following phototherapy, major histologic criteria including density of infiltrate, epidermotropism and lymphocytic atypia along with some minor histologic criteria such as lymphocytic infiltrate and intraepidermal atypical lymphocytes were significantly alleviated after treatment (p < 0.05). Conclusion: We find a significant decrease in some important histologic parameter of MF after phototherapy, indicating these features may be important diagnostic parameters evaluating therapeutic effect of phototherapy.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded132    
    Comments [Add]    

Recommend this journal