Acta Medica International

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 3  |  Issue : 1  |  Page : 132--136

Association between Interleukin-6 (-174 G/C and -572 C/G) promoter gene polymorphisms and risk of intracerebral hemorrhage in North Indian population: A case control study


Pradeep Kumar1, Amit Kumar1, Ram Sagar1, Shubham Misra1, Mohammad Farooq2, Varun Suroliya1, Subiah Vivekanandhan3, Achal Kumar Srivastava1, Kameshwar Prasad1 
1 Department of Neurology, All Institute of Medical Sciences, New Delhi, India
2 Institutes of Genomics and Integrative Biology, New Delhi, India
3 Department of Neurobiochemistry, All Institute of Medical Sciences, New Delhi, India

Correspondence Address:
Kameshwar Prasad
Department of Neurology, Neurosciences Centre, All India Institute of Medical Sciences, Room No. 11, 6th Floor, Ansari Nagar, New Delhi
India

Background: Interleukin-6 (IL-6), a pro-inflammatory cytokine is involved in various vascular pathologies including stroke. Till date, no studies have been reported for the association between IL-6 gene polymorphisms with the risk of Intracerebral hemorrhage (ICH). Objective: The aim of this present case-control study was to investigate the association between IL-6 (-174 G/C and -572 C/G) gene polymorphisms and risk of ICH in North Indian population. Methods: Genotyping was carried out by using SNaPshot method for ICH patients and 100 age-sex matched ICH free controls. Conditional logistic regression analysis with adjusting multiple demographic and risk factor variables was used to calculate the strength of association between IL-6 (-174 G/C and -572 C/G) polymorphisms and risk of ICH. Results: Hypertension, diabetes, dyslipidemia, smoking and low socioeconomic status were found to be associated with the risk of ICH. The distribution of -174 G/C and -572 C/G genotypes was consistent with Hardy Weinberg Equilibrium (HWE) in the ICH and control subjects. Conditional logistic regression analysis showed a significant association between IL-6 -572 C/G gene polymorphism and the risk of ICH under dominant model (OR=3.7; 95%CI 1.05 to 13.1; p=0.004) and allelic model (OR=2.6; 95%CI 1.1 to 6.2; p=0.01). No significant association was observed for the association between IL-6 -174 G/C gene polymorphism and risk of ICH. Conclusion: Our results suggest that IL-6 (-572 C/G) polymorphism is significantly associated with the risk of ICH in North Indian population. Further prospective studies with large sample size are needed for independent validation.


How to cite this article:
Kumar P, Kumar A, Sagar R, Misra S, Farooq M, Suroliya V, Vivekanandhan S, Srivastava AK, Prasad K. Association between Interleukin-6 (-174 G/C and -572 C/G) promoter gene polymorphisms and risk of intracerebral hemorrhage in North Indian population: A case control study.Acta Med Int 2016;3:132-136


How to cite this URL:
Kumar P, Kumar A, Sagar R, Misra S, Farooq M, Suroliya V, Vivekanandhan S, Srivastava AK, Prasad K. Association between Interleukin-6 (-174 G/C and -572 C/G) promoter gene polymorphisms and risk of intracerebral hemorrhage in North Indian population: A case control study. Acta Med Int [serial online] 2016 [cited 2019 Dec 10 ];3:132-136
Available from: http://www.actamedicainternational.com/article.asp?issn=2349-0578;year=2016;volume=3;issue=1;spage=132;epage=136;aulast=Kumar;type=0