Acta Medica International

CASE REPORT
Year
: 2015  |  Volume : 2  |  Issue : 2  |  Page : 186--188

A 3-way rare variant Ph translocation t(7;9;22) in a patient with chronic myeloid leukemia


Saira Shan1, Muhammad Nadeem2, Tabbassum Ara3, Tahir Shamsi4 
1 Department of Cytogenetics, National Institute of Blood Disease & Bone Marrow Transplantation, Karachi, Pakistan
2 Head of Pathology, Molecular Biology and Cytogenetics, National Institute of Blood Disease & BMT, Karachi, Pakistan
3 Medical Lab Technologist, National Institute of Blood Disease & BMT, Karachi, Pakistan
4 Department of Haematologist & Transplant Physician, National Institute of Blood Disease & BMT, Karach, Pakistan

Correspondence Address:
Saira Shan
Department of Cytogenetics, National Institute of Blood Disease & Bone Marrow Transplantation, ST 2/A Block 17 Gulshan-e-Iqbal, KDA Scheme 24 Karachi
Pakistan

Chronic Myeloid Leukemia (CML) is associated with translocation between chromosome 9 & chromosome 22, t(9;22)(q34;q11.2) and with the formation of BCR-ABL fusion gene. In few newly diagnosed CML cases, complex cytogenetics variants of the Philadelphia (Ph) chromosome can be observed with the involvement of a third chromosome other than chromosome 9 & chromosome 22. Here in, we describe a 45 yrs old male, diagnosed as CML in Chronic phase with a complex translocation involving chromosomes 7, 9 & 22. Cytogenetics investigations for confirmation of CML revealed 46,XY, t(7;9;22)(q11.2;q34;q11.2) in 100% metaphases counted. Fluorescence in-situ hybridization (FISH) showed BCR-ABL fusion signals pattern in 100% nucleated cells analyzed. A review of the literature revealed that CML patients with this translocation tend to have an aggressive course and poor outcome. Additional 3-way chromosome translocations associated with CML are also reviewed.


How to cite this article:
Shan S, Nadeem M, Ara T, Shamsi T. A 3-way rare variant Ph translocation t(7;9;22) in a patient with chronic myeloid leukemia.Acta Med Int 2015;2:186-188


How to cite this URL:
Shan S, Nadeem M, Ara T, Shamsi T. A 3-way rare variant Ph translocation t(7;9;22) in a patient with chronic myeloid leukemia. Acta Med Int [serial online] 2015 [cited 2019 Sep 21 ];2:186-188
Available from: http://www.actamedicainternational.com/article.asp?issn=2349-0578;year=2015;volume=2;issue=2;spage=186;epage=188;aulast=Shan;type=0