• Users Online: 99
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2019  |  Volume : 6  |  Issue : 2  |  Page : 53-57

Impact of CD40 gene polymorphism on coronary artery disease in an Indian population: A pilot study


Department of Biochemistry, AIIMS, Rishikesh, Uttarakhand, India

Correspondence Address:
Dr. Sarama Saha
Department of Biochemistry, AIIMS, Rishikesh, Uttarakhand
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ami.ami_54_19

Rights and Permissions

Context: Coronary artery disease (CAD) is number one killer in India. CD40/CD40 L may have crucial contribution in the development of CAD because of its dual prothrombotic and proinflammatory role. However, no study has been conducted to observe the effect of CD40 gene polymorphism on CAD in Indian populations. Aims: To determine the allelic frequency of CD40 gene and its influence on Indian individuals having unstable chest pain and cardiac muscle infarction which are variants of CAD. Settings and Design: A clinic-based observational study was conducted in Maulana Azad Medical College. Eighty angiographically proven patients of CAD and fifty healthy individuals registered for this study. Materials and Methods: Polymerase chain reaction and restriction fragment length polymorphism were used for studying CD40 gene polymorphism. Statistical Analysis Used: Frequency distribution of genotype was analyzed by standard Chi-square test using SPSS software version 21. Results: The C and T allele frequencies were 71.25% and 28.75%, respectively, in diseased individuals. Significant difference was observed among patients with CAD and healthy references regarding distribution of genotypes (χ2 = 10, P = 0.007) although allele frequencies (χ2 = 2.94, P = 0.09) of CD40 gene did not show any significance. The presence of C allele augmented the chance of having CADs compared to the wild type (odds ratio: 1.13; 95% confidence interval: 0.687–1.887). Conclusions: Important correlation was noted between rs1883832 C/T polymorphism of CD40 gene and risk of development of CADs among Indian populations.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed365    
    Printed16    
    Emailed0    
    PDF Downloaded40    
    Comments [Add]    

Recommend this journal