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ORIGINAL ARTICLE
Year : 2017  |  Volume : 4  |  Issue : 1  |  Page : 51-55

Soluble HLA-G: A novel marker in acute myeloid leukemia patients


1 Department of Clinical Haematology, Faculty of Medicine, Alexandria University, Alexandria, Egypt
2 Department of Clinical Pathology, Military Medical Academy, Alexandria, Egypt
3 Department of Clinical Haematology, Military Medical Academy, Alexandria, Egypt

Correspondence Address:
Nahla Abdel Moneim Hamed
Department of Clinical Haematology, Faculty of Medicine, Alexandria University, Alexandria
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.5530/ami.2017.4.10

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Objective: to study soluble HLA-G (sHLA-G) in Egyptian acute myeloid leukemia (AML) patients. HLA-G is speculated to be a tumor-driven immune escape mechanism. In addition, it might be a promising target for future immune therapeutic approaches. Methods: Thirty AML patients and 15 healthy controls of matched age and sex were the subject of the study. sHLA-G was done to all patients and controls by ELISA. Results: Statistically significant increase in sHLA-G level was present in AML patients compared to controls, being higher in relapsed cases. HLA-G levels was correlated to bone marrow blast percentages but not affected by age, gender, WBCs or response to chemotherapy. HLA-G had a sensitivity of 100% and a specificity of 62% to detect AML cases. Conclusion: HLA-G may be an additional marker for AML especially relapsed cases


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