• Users Online: 638
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2016  |  Volume : 3  |  Issue : 1  |  Page : 111-115

Association of VDR FokI and ApaI genetic polymorphisms with parkinson's disease risk in South Western Iranian population


Department of Cell and Molecular Biology, Maragheh University, Maragheh, Iran

Correspondence Address:
Reza Mohammadzadeh
Department of Cell and Molecular Biology, Maragheh University, Maragheh
Iran
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.5530/ami.2016.1.24

Rights and Permissions

Background: Parkinson's disease comes second comparing to Alzheimer's disease being responsible for nerve destructing diseases; it is a complex and multifactorial disease. Gene associated studies help to identify the genetic factors that introduce the Single Nucleotide Polymorphisms in different genes as genetic risk factors for non-Mendelian Parkinson's disease in diverse populations. We intended to study the association of VDR (Vitamin D Receptor) gene polymorphisms with Parkinson's disease in south western Iranian population. Results: In the present study 150 patients with Parkinson's disease and 160 Healthy controls from an Iranian population were genotyped for two polymorphic sites. The prevalence of VDR polymorphisms in two restriction fragment length polymorphism sites including FokI and ApaI were analyzed in patients and controls. Our data demonstrated no significant association between VDR FokI polymorphism and PD, whereas the ApaI polymorphism showed a significant association with PD in Iranian patient. Also no association between the age at onset, the male-female ratio and the VDR polymorphism in the PD group was detected. Conclusions: In conclusion these results determined that VDR ApaI (TG and GG) genotype might affect development of PD in our study population. There was no association between FokI polymorphism and the risk of PD. Our results were analogous only with American/Hungarian Caucasian race.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed751    
    Printed30    
    Emailed0    
    PDF Downloaded54    
    Comments [Add]    

Recommend this journal