• Users Online: 571
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2015  |  Volume : 2  |  Issue : 2  |  Page : 51-53

HOXA9 gene expression and cytogenetic analysis in Egyptian acute myeloid leukemia patients


1 Department of Hematology, Faculty of Medicine, Faculty of Science, Alexandria University, Egypt
2 Department of Biochemistry, Faculty of Medicine, Faculty of Science, Alexandria University, Egypt
3 Department of Medical Biochemistry, Faculty of Medicine, Faculty of Science, Alexandria University, Egypt

Correspondence Address:
Nahla A. M Hamed
Professor of Haematology, Internal Medicine Department, Faculty of Medicine, Alexandria University
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.5530/ami.2015.3.1

Rights and Permissions

Aim: we investigatedthe frequency of expression of HOXA9 gene in adult Egyptian acute myeloid leukemia (AML) patients and its relation to different cytogenetic abnormalities. Methods: 30 newly diagnosed AML patients (group 1) were the subject of our study. Ten healthy persons of matched age and sex were considered group ll (controls). Estimation of HOXA9 expression in AML blasts by RT-PCR was done to both groups. Results: Normal cytogenetic analysis was present in 20 cases (66.6%), t(15,17) in 3 cases, t(8,21) in 3 cases, 45 xy -7 in 1 case, t(16,16) in 1 case, 45 xy-20 in 1 case and 46 XX 1P+ in 1 case. NUP 98 -HOXA 9 gene was not detected in any of the studied case or in the control group. Conclusion: absence of HOXA9 gene in our randomly selected patientsmay be related to its rarity in Egyptian population. However, further studies including larger population is still needed to confirm this finding with special stress on poor cytogenetic group


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed586    
    Printed25    
    Emailed0    
    PDF Downloaded49    
    Comments [Add]    

Recommend this journal