• Users Online: 92
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2015  |  Volume : 2  |  Issue : 2  |  Page : 19-27

Association of CYP3A4*1B and CYP3A5*3 genetic polymorphisms with lung cancer and its impact on taxane metabolism in Indian population


1 Genetics Department, Bhagwan Mahavir Medical Research Centre, Mahavir Marg, Masab Tank, Hyderabad- 500004, Telangana, India
2 Medical Oncologist and Hematologist, ClinSyn Clinical Research Pvt. Ltd, 4-1-1, Hyatnagar, Hyderabad, Telangana, India

Correspondence Address:
Kaiser Jamil
Head of Genetics Department, Bhagwan Mahavir Medical Research Centre, # 10-1-1, Mahavir Marg, Masab Tank, Hyderabad-500004, Telangana
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.5530/ami.2015.2.6

Rights and Permissions

Background: The purpose of this study was to investigate the genotype frequencies of CYP3A4*1B and CYP3A5*3 in lung cancer patients which may be useful in determining the patients' predisposition to platinum based therapies, and may be helpful for individualized drug dosing and improved therapeutics and disease management. Results: We evaluated these two common polymorphisms in south Indian population, based on case-control study of 126 lung cancer cases and 111 controls using a PCR-RFLP-based assay. The investigation of the CYP3A4*1B gene polymorphism revealed, no significant difference in distribution between the lung cancer patients and the controls (p=0.65) . The distribution of CYP3A5*3 homozygous genotypes and heterozygous plus homozygous genotypes were significantly associated (p=0.0004 & p=0.0001) with lung cancer patients, and the *3/*3 genotype had a 4.38 fold increased risk for lung cancer. In our study *1A/*1B heterozygous genotype patients were found to constitute a major percentage of patients receiving Gemcitabine plus carboplatin therapy. Conclusions: In conclusion, the results of our study indicated a relationship between CYP 3A4*1B and CYP3A5*3 polymorphisms and genetic predispositions to lung cancer. Thus detection of CYP3A4*1B/CYP3A4 and CYP3A5*3/CYP3A5 genotype frequencies in Indian population may be important in view of interindividualized drug dosing, improved therapeutics and disease management.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed714    
    Printed16    
    Emailed0    
    PDF Downloaded58    
    Comments [Add]    

Recommend this journal