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CASE REPORT
Year : 2015  |  Volume : 2  |  Issue : 2  |  Page : 191-194

Tuberous sclerosis with bipolar disorder mania: Genetic perspective


Assistant Professor in Psychiatry, Teerthanker Mahaveer Medical College, Moradabad.(U.P), , Associate Professor in Medicine, Teerthanker Mahaveer Medical College, Moradabad.(U.P), India

Correspondence Address:
Prerana Gupta
Assistant Professor in Psychiatry, Teerthanker Mahaveer Medical College, Moradabad.(U.P)
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.5530/ami.2015.5.6

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Tuberous sclerosis or tuberous sclerosis complex (TSC) is a rare multi-system genetic disease that causes non-malignant tumors to grow in the brain and on other vital organs such as the kidneys, heart, eyes, lungs, and skin. Non specific psychiatric symptoms occur in substantial number of patients with Tuberous Sclerosis. Tuberous Sclerosis is a rare disorder and most of patients present with behavioural changes, which may be mistaken for variety of psychiatric disorders, though Mania has been rarely reported. Here we report a case of Tuberous Sclerosis with classic radiological findings and manic features. Skin showed typical facial angiofibromas and Ash leaf macules and MRI displayed classic Tubers. There have been very few case reports of Bipolar disorder manic phase and all studies have till now proposed the anatomical relation of tubers in the brain as the underlying mechanism of this psychopathology. The neuroanatomical abnormalities found in this patient could be a possible explanation of his manic symptoms.


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