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ORIGINAL ARTICLE
Year : 2015  |  Volume : 2  |  Issue : 2  |  Page : 108-111

Prevalence of VKORC1 polymorphism in population of Hyderabad India


1 Research Associate, Tapadia Diagnostic Centre Pvt Ltd, Hyderabad, India
2 R&D Director, Tapadia Diagnostic Centre Pvt Ltd, Hyderabad, India
3 Director, Tapadia Diagnostic Centre Pvt Ltd, Hyderabad, India
4 Director Technical, SLS Cell Cure Technologies Pvt Ltd, Hyderabad, India

Correspondence Address:
Livy Alex
Director Technical, SLS Cell Cure Technologies Pvt Ltd, 103; Prabhat Apartments, Street No 11, East Marredpally, Secunderabad-500026
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.5530/ami.2015.4.1

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Introduction: Warfarin/Acitrom administration dosage varies based on patient genotype with respect to the gene: Vitamin K epoxide reductase complex 1 (VKORC1). Ethnic diversity contributes to genotype variation. The frequency of polymorphism at VKORC1 in population of Hyderabad has not been reported in literature; hence the present study was conducted. Material & Methods: Genomic DNA from peripheral blood leukocytes of patients on warfarin/acitrom as well as normal control population without any thrombotic disease was extracted and Restriction Fragment Length Polymorphism (RFLP) pattern was established for 1173C>T transition by standard protocols. Result: The incidence of homozygote dominants (CC) genotypes were 74.63% and that of heterozygotes (CT) were 25.37 %. No recessives were found in the study group. Conclusion: Presently genotype based dosage is not implemented. This study through its collaboration with practising cardiologist while establishing the test at our diagnostic centre has also enabled awareness and consequently if followed will improve patient safety.


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